In 1949, the first Sister in the new Boston novitiate made her profession. Beyond that, the Columban Sisters soon discovered that Boston was fertile ground for missionary vocations. By the late 1950s there were 26 novices living in their Hyde Park residence, and the Columban Sisters were soon to discover new friends. While still in temporary vows, the Sisters took courses at Emmanuel College and Regis College. Thanks to the generosity of the Sisters of Notre Dame de Namur and the Sisters of St. Joseph, all of the Columban Sisters were awarded full scholarships. Following completion of their studies, the Columban Sisters were then missioned to the Philippines, Korea, and Hong Kong.

Today, there are just under 200 Columban Sisters working in Chile, China, England, Ireland, Korea, Myanmar, Pakistan, Peru, the Philippines, Scotland, and the United States. Vocations continue, but in the missionary spirit of the day, the Columban Sisters maintain novitiates in South America and Myanmar.

Frank Mazzaglia is associated with the Missionary Alliance which is comprised of religious missionary congregations of priests, sisters, brothers, and lay people whose members toil in the vineyards for Christ all over the world.